Choose your preferred dates
Select one of the available date combinations below to check the latest Prague–Santiago prices and availability on Aviasales. Schedules are broadly similar across the listed dates, although some outbound journeys take approximately 27 hours and 35 minutes.
How to book this deal
Open the flight results
Select your preferred dates and open the available American Airlines itineraries on Aviasales.
Review the full itinerary
Compare the total journey time, US connection lengths, baggage allowance and travel suppliers displayed.
Complete your booking
Continue to your selected travel supplier and confirm that the carry-on and 23 kg checked bag remain included.
Fares were found from approximately €571 with carry-on baggage and one checked bag up to 50 lb, approximately 23 kg, included. Prices and availability can change at any time. Confirm the final baggage allowance, US transit requirements, connection times, fare rules and supplier conditions before payment.
Excellent Chile pricing for travellers willing to accept a long journey
Return flights from Prague to Santiago de Chile are available from approximately €571 with American Airlines.
The fare includes carry-on baggage and one checked suitcase up to 50 lb, approximately 23 kg. This significantly strengthens the value compared with a stripped-down long-haul fare.
Eight date combinations were found across August and September, with trip lengths ranging from approximately nine nights to more than two weeks.
The main compromise is the routing. Both directions involve two US connections, normally through Philadelphia and Miami, with total journey times of approximately 26 to 28 hours outbound and around 29 hours on the return.
Some dates have an outbound duration of around 27 hours and 35 minutes, while the return itinerary remains broadly similar across the available combinations.
The flight times themselves are generally reasonable, but the number of sectors, US immigration procedures and long total journey time make this a deal aimed primarily at price-driven travellers.
Flights from Central Europe to Chile can often cost considerably more,
especially when a checked suitcase is added.
At approximately €571 return, this fare provides access to a distant
South American destination at an unusually low price, with a full
baggage allowance already included.
Both directions transit the United States. Travellers generally need
an approved ESTA or the appropriate US visa, even when only changing
flights.
Passengers normally complete US immigration and customs formalities
at the first US airport. Checked baggage may need to be collected and
rechecked before continuing, even when all flights are issued on one
ticket.
The cheapest fare may be non-refundable and non-exchangeable. Confirm
all conditions carefully before booking non-refundable accommodation,
internal flights or tours.
Best for: flexible, price-conscious travellers who want to visit Chile with checked baggage included and do not mind a long two-stop itinerary.
Less ideal for: travellers who dislike US transit, multiple connections, long layovers or journeys approaching 30 hours.
Dino’s advice: check every connection carefully before booking and make sure you meet the US transit requirements. At this price, the fare is excellent, but the long routing should be treated as a major part of the decision.
Need help finding the best flight for your trip?
For €15, Dino can personally research flight options for your trip — including alternative routes, nearby airports, baggage rules, layovers, airline quality and possible hidden costs.
Where to stay in Santiago: begin your Chile trip with a central city base
Santiago offers a broad selection of accommodation, ranging from modern business hotels and serviced apartments to stylish boutique properties and international hotel brands.
For our sample search from 19 August to 21 August, well-rated 3 and 4-star hotels in central locations were available from approximately €90 per night.
When travelling as a couple, this works out at around €45 per person per night, offering reasonable value for a comfortable and conveniently located stay in Chile’s capital.
Spending the first two or three nights in Santiago can be a practical way to recover from the long journey, adjust to the local time and explore the city before continuing to other parts of Chile.
Santiago can also serve as a useful starting point for onward travel to the coast, including Valparaíso and Viña del Mar, as well as the surrounding wine regions, the Andes and destinations farther south.
Neighbourhoods such as Providencia, Las Condes, Bellavista and selected parts of the historic centre are commonly considered by visitors. Each offers a different balance of restaurants, transport links, nightlife, sightseeing and hotel pricing.
Before booking, check the property’s distance from a Metro station and the areas you plan to visit. Santiago is a large city, and choosing a well-connected location can reduce daily travel time and make short stays considerably easier.
Dino tip: if you plan to continue toward the coast or begin a longer Chile itinerary, choose a flexible or refundable rate for the first nights. This gives you more freedom if your arrival is delayed or your onward plans change.
Search and compare accommodation in Santiago →Sample prices were checked for 19–21 August for two adults. Prices and availability can change. Confirm the final total, taxes, exact neighbourhood, Metro access, airport-transfer options, breakfast inclusions, recent reviews, room category and cancellation conditions before booking.
Complete Your Trip
Flights and accommodation are the big pieces — now make the journey smoother. Below are three useful extras for this trip: activities, mobile data and airport transfers.
Find tours, day trips, food experiences and activities to make this trip more memorable. A useful place to compare things to do before you travel.
Land with mobile data ready and avoid searching for SIM cards or relying on airport Wi-Fi. A simple option for staying connected while travelling.
A useful option for airport transfers, especially when arriving late, travelling with luggage, or landing somewhere unfamiliar for the first time.
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